2-bromo-5-hydroxy-4-methoxybenzaldehyde

Melting point / freezing point

Administrative data

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1998-04-04 to 1998-04-16

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1998

Report date:

1998

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Deviations:

no

Principles of method if other than guideline:

not applicable

GLP compliance:

yes (incl. QA statement)

Remarks:

: Certificate from the Swiss GLP Monitoring Authority

Type of method:

other: Thermal analysis (Preliminary test) & Capillary test (Main study)

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

426-540-0

EC Name:

-

Cas Number:

2973-59-3

Molecular formula:

C8 H7 Br O3

IUPAC Name:

2-bromo-5-hydroxy-4-methoxybenzaldehyde

Test material form:

solid

Specific details on test material used for the study:

- Batch: 00265786
- Purity: 91.3% (HPLC purity)
- Expiration date: July 1, 1998 (retest date)
- Storage: at room temperature at about 20°C

Results and discussion

Melting / freezing point

Melting / freezing point 1

Key result

Melting / freezing pt.:

>= 86.3 - <= 109.2 °C

Remarks on result:

other: Mean of two tests. Heating rate 1 K/min. The results from the main study performed with the capillary method.

Melting / freezing point 2

Key result

Melting / freezing pt.:

>= 80 - <= 108 °C

Remarks on result:

other: One test. The heating rate 20 K/min. The results from the preliminary study performed with the differential thermal analysis.

Any other information on results incl. tables

Results from the preliminary test: An endothermic heat effect, the melting, was observed under room pressure. The reaction started at about 80 deg C and showed the endothermic maximum at about 108 deg C. After the experiment, the sample had lost about 82 % of its mass and the color of the sample was changed to black.

Results from the main study: In order to determine the melting point more precisely, further tests were performed using the capillary tester. A total of 6 samples was heated with a heating rate of 1 K/mm. The melting range of the samples was determined visually to be between about 86 deg C and 109 deg C. The appearance at 86 deg C corresponds to what is described as stage A in the OECD guideline 102. At 109 deg C a clear brown solution was obtained.

Applicant's summary and conclusion

Conclusions:

In conclusion, the melting range of T002019 is determined to be between 86°C- 109°C (capillary test) and 80°C - 108°C (differential thermal calorimeter method).