4-bromo-2,2-diphenylbutanenitrile

Flammability

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

substances / mixtures which in contact with water emit flammable gases

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the experience in production or handling shows that the substance does not react with water, e.g. the substance is manufactured with water or washed with water

other:

Reference 2

Endpoint:

pyrophoric solids

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is known to be stable in contact with air at room temperature for prolonged periods of time (days) and hence, the classification procedure does not need to be applied

other:

Reference 3

Endpoint:

self-heating substances / mixtures

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is completely molten at 160°C

Reference 4

Endpoint:

flammable solids

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: No information on purity of the substance. Although the study was not performed according to an OECD or EC guideline, the used methodology and the provided data are adequate and sufficient to conclude on the 'flammability solids' endpoint.

Qualifier:

according to guideline

Guideline:

other: VDI Guideline 2263 Part 1, Burning behaviour: Test Methods for the Determination of the Safety Characteristic of Dusts (May 1990)

Deviations:

no

Qualifier:

according to guideline

Guideline:

other: ESCIS Expert Commission for Safety in the Swiss Chemical Industry, Booklet 1 ”Sicherheitstests fur Chemikalien" (1998)

Deviations:

yes

Remarks:

30 min conditioning instead of 1 hour

GLP compliance:

not specified

There is no spreading of fire (class 1: no ignition) at 20 deg C.

Conclusions:

There is no spreading of fire (class 1: no ignition) at 20 at deg C.

Reference 5

Endpoint:

flammable solids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

13 September - 25 November 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

UN Manual of Tests and Criteria: Test N.1 (Test method for readily combustible solids)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Specific details on test material used for the study:

- Batch n°: I16AB0081
- Analytical purity: 99.3%
- Expiration date: 11 January 2018
- Storage condition: at room temperature

Key result

Test procedure:

burning rate test: preliminary screening test

Remarks on result:

substance does not ignite and propagate combustion either by burning with flame or smouldering along 200 mm of the powder train within the 2 minutes test period

In contact with the flame of the gas burner the test item melted, emitted yellow sparks and turned into a light brown residue. Grey smoke was observed. After removal of the ignition source, no propagation of combustion of the test item was observed.

According to the guidelines, performance of the burning rate test is not required. Based on the results obtained, the test item is considered ‘not readily combustible’ (i.e. ‘not flammable’).

Interpretation of results:

not classified based on GHS criteria

Conclusions:

The preliminary screening test was performed for the determination of the flammability of JNJ-1597622-AAA (T000625).

No propagation of combustion of the test item along 200 mm length of the pile within 2 minutes was observed. According to the guidelines, performance of the burning rate test is not required. Based on the results obtained, the test item is considered 'not readily combustible' (i.e. ‘not flammable’).

Description of key information

The flammability potential of T000625 was determined in a GLP study according to the UN N.1 Method (Klimisch 1, Ciric, 2017).

According to the results of the preliminary test, performance of the burning rate test was not required. T000625 is considered as not readily combustible (i.e. not flammable). Furthermore, T000625 is not considered a pyrophoric substance, a self-heating substance or a substance which emits flammable gases after contact with water (no tests performed, waiving based on theoretical assessment and experience in day-to-day handling and use).

Key value for chemical safety assessment

Flammability:

not classified

Additional information

A supporting study is available performed by the Janssen Pharmaceutica Process Safety Center (1990). In this study no spreading of fire was observed and the burning class was determined to be class 1 (no ignition) at 20°C.

Justification for classification or non-classification

The substance does not need to be classified as flammable, self-heating, pyrophoric or as a substance which emits flammable gases in contact with water.