Registration Dossier
Registration Dossier
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EC number: 229-227-5 | CAS number: 6441-82-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database
Data source
Reference
- Reference Type:
- other: authoritative database
- Title:
- Acute inhalation toxicity study in mouse for Bromochloromethane (CAS no: 74-97-5)
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- ChemIDplus, A TOXNET DATABASE, Lite Browse Advanced, 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as metioned below
- Principles of method if other than guideline:
- Acute inhalation toxicity study for Bromochloromethane (CAS no: 74-97-5) in mouse.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Bromochloromethane
- EC Number:
- 200-826-3
- EC Name:
- Bromochloromethane
- Cas Number:
- 74-97-5
- Molecular formula:
- CH2BrCl
- IUPAC Name:
- Bromochloromethane
- Details on test material:
- Name - Bromochloromethane
InChI - 1S/CH2BrCl/c2-1-3/h1H2
Smiles - C(Cl)Br
- Molecular formula (if other than submission substance):CH2BrCl
- Molecular weight (if other than submission substance):129.384 g/mole
- Substance type:Organic
Constituent 1
- Specific details on test material used for the study:
- Name - Bromochloromethane
InChI - 1S/CH2BrCl/c2-1-3/h1H2
Smiles - C(Cl)Br
- Molecular formula (if other than submission substance):CH2BrCl
- Molecular weight (if other than submission substance):129.384 g/mole
- Substance type:Organic
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remark on MMAD/GSD:
- not specified
- Details on inhalation exposure:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 7 h
- Remarks on duration:
- not specified
- Concentrations:
- 12030 mg/m3
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- - Other examinations performed: clinical signs were observed.
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 12 030 mg/m³ air
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed at 12030 mg/m3
- Clinical signs:
- other: Clinical Symptoms like dyspnea and changes in lungs, thorax, muscle weakness and general anesthetic symptoms were observed.
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The acute inhalation toxicity study in mouse by using Bromochloromethane (CAS no: 74-97-5) for exposure of 7 hr was considered to be 12030 mg/m3.
- Executive summary:
The acute inhalation toxicity study was conducted by using Bromochloromethane (CAS no: 74-97-5) in mouse at the concentration of12030 mg/m3. 50% mortality was observed at12030 mg/m3with clinical Symptoms like dyspnea and changes in lungs, thorax, muscle weakness and general anesthetic symptoms were observed, when exposed for 7 hours. Therefore, LC50 was considered to be12030 mg/m3when mouse was treated with Bromochloromethane by inhalation for 7 hours.
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