Registration Dossier
Registration Dossier
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EC number: 446-800-7 | CAS number: 175357-18-3
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: EU guideline, GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 2003-02-13
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- sepiwhite MSH
- IUPAC Name:
- sepiwhite MSH
- Details on test material:
- description: off-white powder
batch number: 0214400005
received: 13 October 2003
storage conditions: approximately 4°C in the dark
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficientopen allclose all
- Type:
- log Pow
- Partition coefficient:
- ca. 3.3
- pH:
- ca. 2
- Remarks on result:
- other: HPLC method
- Type:
- log Pow
- Partition coefficient:
- ca. -0.04
- pH:
- ca. 7
- Remarks on result:
- other: calculated
Applicant's summary and conclusion
- Conclusions:
- The partition coefficient of the test material has been determined to be 2.14/10^3, log 10 Pow 3.33at pH2, log10 Pow -0.04, calculated at pH 7.
- Executive summary:
Partition coefficient.
2.14*10^3, log Pow 3.33 at pH 2, using the HPLC method, Method A8 od Comission Directive 92/69/EEC, log10 Pow -0.04, calculated at pH 7.
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