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EC number: 607-813-5
CAS number: 25830-77-7
The majority of auricular lymph nodes across all test item treated
groups were considered slightly enlarged. No macroscopic abnormalities
of the surrounding area were noted for any of the animals.
In a GLP-compliant OECD Guideline 429 study
(LLNA assay), the test substance at concentrations 10%, 25% and 50%
solution in dimethylformamide induced the Stimulation Indices of 12.0,
5.9 and 5.2. Mean DPM/animal values for the experimental groups treated
with test item concentrations 10, 25 and 50% were 9361, 4624 and 4054
DPM, respectively. The mean DPM/animal value for the vehicle control
group was 780 DPM. No mortality occurred and no clinical signs of
systemic toxicity were observed in the animals of the main study. Body
weights and body weight gain of experimental animals remained in the
same range as controls over the study period. The majority of auricular
lymph nodes across all test item treated groups were considered slightly
enlarged. No macroscopic abnormalities of the surrounding area were
noted for any of the animals. The validity of the study was confirmed by
reliability check with Alpha-hexylcinnamaldehyde performed not more than
6 months previously at the same test facility. The
mean DPM/animal value for 25% alpha-hexylcinnamaldehyde was 4551 ± 643.
The respective Stimulation Index was calculated to be 4.4. Based
on the results of the study, the test substance is considered to be
sensitizing to skin under the conditions of the assay and should be
classified as Skin Sens. 1, H317 under Regulation 1272/2008/EC.
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