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Diss Factsheets
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EC number: 611-278-3 | CAS number: 55502-61-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Planned changes to the study plan can be made at the discretion of the study director and will be agreed with the Sponsor. Detailed descriptions of all study plan amendments will be effective at the time of study director’s signature. All such amedments w
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-Cyano-3-(3,4-dimethoxyphenyl)propanoic acid
- EC Number:
- 611-278-3
- Cas Number:
- 55502-61-9
- Molecular formula:
- C12H13NO4
- IUPAC Name:
- 2-Cyano-3-(3,4-dimethoxyphenyl)propanoic acid
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- >= 0.67 - <= 3
- Max. score:
- 3
- Reversibility:
- fully reversible
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- >= 0 - <= 1
- Max. score:
- 1
- Reversibility:
- fully reversible
- Remarks on result:
- other: In one rabbit full inspection was not possible at 48h. At both 24 and 72 hours, the coreneal and iris scores were zero, so although the eye was closed at 48 hours, it was assumed that therw were no corneal or iris effects at the 48 hour time point.
- Remarks:
- In one rabbit full inspection was not possible at 48h. At both 24 and 72 hours, the coreneal and iris scores were zero, so although the eye was closed at 48 hours, it was assumed that therw were no corneal or iris effects at the 48 hour time point.
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- >= 0 - <= 1
- Max. score:
- 1
- Reversibility:
- fully reversible
- Remarks on result:
- other: In one rabbit full inspection was not possible at 48h. At both 24 and 72 hours, the coreneal and iris scores were zero, so although the eye was closed at 48 hours, it was assumed that therw were no corneal or iris effects at the 48 hour time point.
- Remarks:
- In one rabbit full inspection was not possible at 48h. At both 24 and 72 hours, the coreneal and iris scores were zero, so although the eye was closed at 48 hours, it was assumed that therw were no corneal or iris effects at the 48 hour time point.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- >= 2 - <= 2.67
- Max. score:
- 2.67
- Reversibility:
- fully reversible
- Remarks on result:
- other: mean value could not be calculated because redness was not observable at 48 hours.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2A (irritating to eyes) based on GHS criteria
- Conclusions:
- The test item Cianacido, applied to the rabbits eye mucosa, caused significant conjunctival and corneal irritant effects, corneal opacity in one rabbit but no iris effects. The effects were reversible within three weeks. The severity prevented full scoring in one rabbit but for classification according to the EC criteria, the test item should be classified as H319 on basis of the observed conjunctival irritation.
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