Registration Dossier
Registration Dossier
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EC number: 204-077-3 | CAS number: 115-27-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study undertaken and reported scientifically but not to GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,4,5,6,7,7-hexachloro-8,9,10-trinorborn-5-ene-2,3-dicarboxylic anhydride
- EC Number:
- 204-077-3
- EC Name:
- 1,4,5,6,7,7-hexachloro-8,9,10-trinorborn-5-ene-2,3-dicarboxylic anhydride
- Cas Number:
- 115-27-5
- Molecular formula:
- C9H2Cl6O3
- IUPAC Name:
- 1,4,5,6,7,7-hexachloro-8,9,10-trinorborn-5-ene-2,3-dicarboxylic anhydride
- Details on test material:
- - Name of test material (as cited in study report): Chlorendic anhydride- Analytical purity: 98.81%- Lot/batch No.: 3-12-206
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Source: - Age at study initiation: - Weight at study initiation: 2302 to 2557 g- Fasting period before study: - Housing: Hanging wire-mesh cages- Diet: Purina rabbit chow, ad libitum - Water: ad libitum- Acclimation period:ENVIRONMENTAL CONDITIONS- Temperature (°C): - Humidity (%): - Air changes (per hr): - Photoperiod (hrs dark / hrs light): IN-LIFE DATES: From: To:
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE- Area of exposure: - % coverage: - Type of wrap if used: REMOVAL OF TEST SUBSTANCE- Washing (if done): Washed with tepid water- Time after start of exposure: 24 hoursTEST MATERIAL- Amount(s) applied (volume or weight with unit): 10000 and 20000 mg / kg- Concentration (if solution): - Constant volume or concentration used: yes/no- For solids, paste formed: noVEHICLE- Amount(s) applied (volume or weight with unit):- Concentration (if solution):- Lot/batch no. (if required): - Purity:
- Duration of exposure:
- 24 hours
- Doses:
- 10000 and 20000 mg / kg.
- No. of animals per sex per dose:
- 1
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days- Frequency of observations and weighing: At 24 hours and then daily- Necropsy of survivors performed: no- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 - < 20 000 mg/kg bw
- Mortality:
- Both male rabbits at the 20000 mg / kg dosage level died during the 14 day observation period. None of the other rabbits died.
Applicant's summary and conclusion
- Interpretation of results:
- relatively harmless
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- Based upon the results obtained, the test material would not be classified as harmful.
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