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EC number: 201-004-7 | CAS number: 77-09-8
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2010-05-25 to 2010-05-26
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- 2006
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- 2008
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- effusion method: vapour pressure balance
- Key result
- Temp.:
- 20 °C
- Vapour pressure:
- < 0 hPa
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- < 0 hPa
- Key result
- Temp.:
- 50 °C
- Vapour pressure:
- < 0 hPa
- Conclusions:
- The measured vapour pressure was below 10-5 hPa. For a conservative estimation, it was assumed that the vapour pressure at 149.8 °C corresponds to the lower detection limit of the vapour pressure balance, i.e. 10-5 hPa. Based on this assumption the calculated vapour pressure values are << 0.0000001 hPa at 20, 25 and 50 °C.
- Executive summary:
A study was conducted to determine the vapour pressure of the test item according to OECD Guideline 104 (2006) and European Commission Regulations EC No. 440/2008 method A.4. Therefore, the effusion method (vapour pressure balance) was used. The measured vapour pressure was below 10-5 hPa. For a conservative estimation, it was assumed that the vapour pressure at 149.8 °C corresponds to the lower detection limit of the vapour pressure balance, i.e. 10 -5 hPa. Based on this assumption the calculated vapour pressure values are << 0.0000001 hPa at 20, 25 and 50 °C.
Reference
The vapour pressure was measured in the temperature range of 20 °C to 150 °C. No vapour pressure of the test item above the lowest detection limit of 10-5hPa was observed in the entire temperature range. For every temperature the vapour pressure of the test item was < 10-5hPa. The vapour pressure was estimated at 20, 25 and 50 °C based on the Antoine equation. For a conservative estimation of the vapour pressure of the test item a slope of -5000 was used. The last data point of the measurement at 149.8 °C was used as the starting point for the calculation. The measured vapour pressure was below 10-5hPa. For a conservative estimation, it was assumed that the vapour pressure at 149.8 °C corresponds to the lower detection limit of the vapour pressure balance, i.e. 10-5hPa. Based on this assumption, the constant A of the Antoine equation was calculated according to
A = log p - [B / (273.15 + T)] = log 10-5- [-5000 / (273.15 + 149.8)]= 6.8217
Subsequently, the vapour pressure at 20, 25 and 50 °C can be calculated with the Antoine equation as follows:
log p = 6.8217 - 5000 / (273.15 +T) (p in hPa and T in °C)
T in °C |
p in hPa |
p in Pa |
20 |
5.83 x 10-11 |
5.83 x 10-9 |
25 |
1.13 x 10-10 |
1.13 x 10-8 |
50 |
2.23 x 10-9 |
2.23 x 10-7 |
This is a conservative estimation of the vapour pressure of the test item for the listed temperatures. Since the true vapour pressure is most likely to be even much lower than this value derived from the detection limit, it may safely be assumed that the vapour pressure at the above listed temperatures is far below 10-7hPa (10-5 Pa).
Description of key information
The measured vapour pressure was below 10-5 hPa. For a conservative estimation, it was assumed that the vapour pressure at 149.8 °C corresponds to the lower detection limit of the vapour pressure balance, i.e. 10-5 hPa. Based on this assumption the calculated vapour pressure values are << 0.0000001 hPa at 20, 25 and 50 °C (reference 4.6-1).
Key value for chemical safety assessment
Additional information
A study was conducted to determine the vapour pressure of the test item according to OECD Guideline 104 (2006) and European Commission Regulations EC No. 440/2008 method A.4. Therefore, the effusion method (vapour pressure balance) was used. The measured vapour pressure was below 10-5 hPa. For a conservative estimation, it was assumed that the vapour pressure at 149.8 °C corresponds to the lower detection limit of the vapour pressure balance, i.e. 10-5 hPa. Based on this assumption the calculated vapour pressure values are << 0.0000001 hPa at 20, 25 and 50 °C.
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