Pyridine-2-thiol 1-oxide, sodium salt

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2001

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Pyridine-2-thiol 1-oxide, sodium salt

EC Number:

223-296-5

EC Name:

Pyridine-2-thiol 1-oxide, sodium salt

Cas Number:

3811-73-2

Molecular formula:

C5H5NOS.Na

IUPAC Name:

sodium (1-oxo-1λ⁵-pyridin-2-yl)sulfanide

Details on test material:

- Analytical purity: 92.5%
- Lot/batch No.: 3811-73-2/SB-D010010

Test animals

Species:

rabbit

Strain:

New Zealand White

Details on test animals or test system and environmental conditions:

-Source: Charles River Germany
-Weight: 1.7-1.8kg
-Sex: Female

Test system

Type of coverage:

semiocclusive

Preparation of test site:

shaved

Vehicle:

unchanged (no vehicle)

Controls:

no

Amount / concentration applied:

-0.5g test substance

Duration of treatment / exposure:

-Duration: 4h
-Removal: Wiped off with wet cellulose tissue

Observation period:

14 days

Number of animals:

3

Details on study design:

-Examination time points: 1, 24, 48, 72 h and 6, 8, 10, 14 days
-Scoring: OECD scheme

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Score:

1.9

Remarks on result:

other: average score

Results 2

Irritation parameter:

edema score

Score:

1.7

Remarks on result:

other: average score

Irritant / corrosive response data:

Erythema/eschars: In 2/3 animals changes were seen already 1 h p.a., lasting until 10 days p.a. Eschar formation was noted from 48 h or 72 h p.a. onwards. Eschars desquamated with time and normal skin was visible beneath 14 days p.a.
Oedema: In all animals oedema were noted already 1 h after patch removal. 2/3 animals oedema were noted from 24 h until 6 resp. 10 days p.a. All control areas were normal at each observation time.

Any other information on results incl. tables

Table A6.1.4-S1.           Table for skin irritation study
score (average animals investigated)	time	Erythema	Edema
average score Draize scores (0 to maximum 4)	60 min	0.7	2
	24 h	1	1.3
	48 h	2	1.7
	72 h	2.7	2
average score	24h, 48h, 72h	1.9	1.7
other times	6 d	2.7	1.3
other times	8 d	2.7	0.7
other times	10 d	1.7	0
other times	14 d	0	0
reversibility: *		c	c
time for reversibility		14 days	14 days
*             c :           completely reversible                n c :       not completely reversible                n :          not reversible

Applicant's summary and conclusion

Interpretation of results:

irritating

Remarks:

Migrated information

Conclusions:

According to the EU classification criteria Natrium Pyrion is irritating to the skin. The information contained within this robust summary document comes from studies which are in the ownership of Arch Chemicals Inc. and which are protected in several regions globally. This information may not be used for any purpose other than in support of the Chemical safety Report submitted by Arch Chemicals Inc. under Regulation EC 1907/2006.