Registration Dossier
Registration Dossier
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EC number: 203-470-7 | CAS number: 107-18-6
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Encyclopedia Of Toxicology, Four-Volume Set, Second Edition: 1-4
- Author:
- Philip Wexler
- Year:
- 2 005
- Bibliographic source:
- Encyclopedia Of Toxicology, Four-Volume Set, Second Edition: 1-4, Phylip Wexler, Academic Press, 2005
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Allyl alcohol
- EC Number:
- 203-470-7
- EC Name:
- Allyl alcohol
- Cas Number:
- 107-18-6
- Molecular formula:
- C3H6O
- IUPAC Name:
- prop-2-en-1-ol
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Doses:
- 1.5 mmol/kg
- Control animals:
- not specified
Results and discussion
Effect levels
- Remarks on result:
- other: development of hemolysis in ~50% of the animals
Applicant's summary and conclusion
- Conclusions:
- Intraperitoneal administration of 1.5 mmol/kg bw of allyl alcohol to starved Swiss albino mice causes the development of hemolysis in ~50% of the animals.
Other toxic effects include renal necrosis, pulmonary edema, and central nervous system effects at higher dose levels.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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