1,10-decanediyl bismethacrylate

Endpoint summary

Description of key information

No experimental toxicokinetic study is available on 1,10-decanediol dimethacrylate. However, as per REACH guidance document R7.C (2014), information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties.
Based on the toxicological data and the physicochemical properties, the absorption of  1,10-decanediol dimethacrylate is expected to be low by oral route, dermal route and inhalation.

Key value for chemical safety assessment

Bioaccumulation potential:

no bioaccumulation potential

Absorption rate - oral (%):

50

Absorption rate - dermal (%):

10

Absorption rate - inhalation (%):

100

Additional information

No experimental toxicokinetic study is available on 1,10-decanediol dimethacrylate. However, as per REACH guidance document R7.C (2014), information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties, including:

-Mean molecular weight: 310 g/mol

-Water solubility: 138,6 µg/L (20°C) (insoluble)

-Partition coefficient Log Kow: > 6.5

-Vapour pressure: 0.0329 Pa (25°C)

 

ABSORPTION

The high value of log Kow (>6,5) and the low solubility (< 1 mg/L) of 1,10-decanediol dimethacrylate are favourable for a low oral absorption. Indeed, no clinical effects or mortality were observed after one single administration (5000 mg/kg) of 1,10 -decanediol dimethacrylate by gavage (oral route) in rats.

An oral absorption is expected to be low for 1,10 -decanediol dimethacrylate; the worst case value for oral absorption was taken into account: 50%.

With a solubility < 1 mg/L, dermal absorption is anticipated to be low. A high value of Log Kow suggests that the rate of penetration of the substance may be limited by the rate of transfer between the stratum corneum and the epidermis. However, a molecular mass smaller than 500 g/mol are favourable to a dermal absorption. The methacrylates are known to bind to skin components, and this binding decreases their dermal absorption. Indeed, thedermal absorption of 1,10 -decanediol dimethacrylate is anticipated to be low. The low dermal absorption can be confirmed in the dermal acute toxicity study, where no major systemic effect or mortality were observed in rats treated with 2000 mg/kg bw. However, 1,10 -decanediol dimethacrylate showed allergic reaction in the LLNA: it is evidence that some uptake must have occurred although it may only have been a small fraction of the applied dose. The worst case value for dermal absorption was taken into account: 10%

Based on the low value of the vapour pressure (<0.1 Pa), 1,10 -decanediol dimethacrylate is not considered as a volatile substance. Moreover, theabsorption by inhalation can be expected to be low for 1,10 -decanediol dimethacrylatebased on the values of water solubility and log kow.The worst case value for inhalation absorption was taken into account: 100%

 

 

DISTRIBUTION and METABOLISM

No specific data is available on the distribution or metabolism of 1,10 -decanediol dimethacrylate. No organ toxicity was showed in the studies.

 

ELIMINATION

Due to the low water solubility and the low molecular mass, the excretion of 1,10 -decanediol dimethacrylate in the urines is expected to be low. An excretion via bile and faeces is possible.