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EC number: 811-188-6 | CAS number: 16184-79-5
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016-01-15 to 2016-02-03
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- 2004
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Version / remarks:
- 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
- Version / remarks:
- 1996
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 1.36
- Temp.:
- 25 °C
- pH:
- 6.68
- Details on results:
- The determined log Pow: 1.36 ± 0.005 (95 % confidence interval).
Quality criteria were met as values of log P derived from individual measurements fell within a range of 0.1 log units. - Conclusions:
- The log Pow of the test substance was determined as 1.36 ± 0.005.
- Executive summary:
The purpose of this study was to determine the partition coefficient of the test item using HPLC method according to EU Method A.8, OECD 117, and OPPTS 830.7570. In the course of this study the partition coefficient (Pow) of the test item was determined using high performance liquid chromatography. The log Pow of the test substance was determined as 1.36 ± 0.005.
Reference
Table 1 Measured and calculated data of test item
|
Retention time (min) |
Log k |
LogPow |
Pow |
Repeatability log unit |
|
|
calculated |
|||
Test item |
3.98 |
-0.261 |
1.36 |
23 |
0.01 |
|
3.99 |
-0.258 |
1.37 |
23 |
|
|
3.98 |
-0.261 |
1.36 |
23 |
|
|
3.99 |
-0.258 |
1.37 |
23 |
|
|
3.98 |
-0.261 |
1.36 |
23 |
|
|
3.98 |
-0.261 |
1.36 |
23 |
|
Mean |
3.98 |
-0.261 |
1.36 |
23 |
- |
Conf. Int. (95%) |
0.01 |
- |
0.005 |
0.3 |
- |
CV % |
- |
- |
- |
- |
- |
Description of key information
The log Pow of the test substance was determined as 1.36 ± 0.005.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.36
- at the temperature of:
- 25 °C
Additional information
The purpose of this study was to determine the partition coefficient of the test item using HPLC method according to EU Method A.8, OECD 117, and OPPTS 830.7570. In the course of this study the partition coefficient (Pow) of SIKA Aldehyde A was determined using high performance liquid chromatography. The log Pow of the test substance was determined as 1.36 ± 0.005.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
