Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-888-1 | CAS number: 75-64-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful to fish
Key value for chemical safety assessment
Additional information
The results as presented by Calamari and co-workers in 1980 indicate that tert-Butylamine is acutely harmful to fish if the test is performed in soft water (hardness: 20 mg CaCO3/L). The LC50 based on measured test item concentrations was determined to be 28 mg/L. The acute toxicity is reduced to a LC50 value of 270 mg/L if the test is performed in hard water with a hardness of 320 mg CaCO3/L. The low LC50 value for fish in soft water might be based on a shift in pH, since the low concentration of CO3- -ions in the test solution did not provide significant buffering capabilities. Unfortunately data on pH values in the test solutions are not presented in the publication, only a 'strong basic dissociation' is mentioned in the context of fish exposed to the test substance in soft water.
The hazard assessment is based on the LC50 value derived from the test using hard water since it is commonly accepted, that within the European Union, surface waters generally have a rather high hardness value. Therefore the LC50 determined in soft water is of low relevance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
