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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

The acute oral toxicity of the test substance was assessed, and the LD50 value was determined to be greater than 2000 mg/kg bodyweight.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Value:
mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion
Value:
mg/kg bw

Additional information

An acute oral toxicity study was performed by Huntingdon Life Sciences, UK, to determine the acute oral toxicity of the test substance. The study was conducted to EC test guideline B1 tris, OECD test guideline 423, as well as EPA and Japanese test guidelines, and complied to GLP.

Groups of six female rats were dosed by oral gavage at 300 and 2000 mg/kg bodyweight, then observed for 14 days prior to necropsy.

No deaths occurred during the study. Clinical signs were observed shortly after dosing, but were seen to resolve quickly. No treatment-related macroscopic pathological signs were observed.

The acute median lethal oral dose (LD50) to rats of the test substance was demonstrated to be greater than 2000 mg/kg bodyweight. On the basis that the acute oral LD50 value is greater than 2000 mg/kg, the substance does not require classification as harmful or toxic by the oral route, according to EC Directive 67/548/EEC.

Justification for classification or non-classification

An assessment of the acute oral toxicity of the test substance was performed. The acute median lethal oral dose (LD50) to rats was found to be greater than 2000 mg/kg bodyweight. The test substance does not require classification according to EC Directive 67/548/EEC on the basis of this result.