Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation / corrosion, other
Remarks:
in silico
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
results derived from a (Q)SAR model, with limited documentation / justification
Justification for type of information:
QSAR prediction

Data source

Reference
Reference Type:
other: Predicted data
Title:
Unnamed
Year:
2015

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: REACH guidance on QSARs R.6, May/July2008
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
(15α)-3,17-Dioxoandrost-4-en-15-yl acetate
EC Number:
613-793-9
Cas Number:
65429-29-0
Molecular formula:
C21H28O4
IUPAC Name:
(15α)-3,17-Dioxoandrost-4-en-15-yl acetate
Test material form:
solid: crystalline
Details on test material:
Test item: acetoxy-adCas No.: 65429-29-0Batch No.: M64027NStorage: 15-30 °C, protected from light and wet

Results and discussion

In vivo

Results
Remarks on result:
no indication of irritation
Remarks:
QSAR prediction

Any other information on results incl. tables

Software Method Alert Predicted value
ChemProp Skin irritation and corrosion Alpha alkynes Structural Alerts were found. save
Toxtree Skin irritation / skin corrosion No Structural Alerts were found. Not Irritating or Corrosive to skin

(PII: 1)

GHS classification: Not irritating

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
According to (Q)SAR modells: QSAR Toolbox, Toxtree, ChemProp, the predicted values indicated that acetoxy-ad is not irritating. The result meets the requirement of No Hazard Category.