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EC number: 277-753-9
CAS number: 74186-17-7
There is one acute toxicity study available. After single oral
administration no adverse effects were recorded at a dose of 2000 mg/kg
bw in rats using the fixed dose method.
Appendix 1 Individual Clinical
Observations and Mortality Data
Dose Level mg/kg
Animal Number and Sex
Effects Noted After Dosing(Hours)
Effects Noted During Period After Dosing(Days)
0= No signs of systemic toxicity
H = Hunched
F = Red/brown or red colored
staining of feces in the cage
U = Red/brown or red colored
staining of urine in the cage
Appendix 2 Individual Body
Weights and Body Weight Changes
Animal Numberand Sex
Body Weight (g) at Day
Body Weight Gain (g) During Week
Appendix 3 Individual Necropsy
Time of Death
Killed Day 14
No abnormalities detected
The study was performed to assess the
acute oral toxicity of the test item in the Wistar strain rat.
A group of three fasted females was
treated with the test item at a dose level of 2000 mg/kg body
weight. This was followed by a further group of three fasted females at
the same dose level. Dosing was performed sequentially.
The test item was administered orally
as a suspension in distilled water. Clinical signs and body weight
development were monitored during the study. All animals were subjected
to gross necropsy.
were no deaths.
Clinical Observations. Hunched
posture and tiptoe gait were noted during the day of dosing in the first
group of three animals. There were no signs of systemic toxicity noted
in the second group of three animals. Red/brown or red colored staining
of the feces and urine was noted in the cages of all animals.
Body Weight. All
animals showed expected gains in body weight.
abnormalities were noted at necropsy.
The acute oral median lethal dose (LD50)
of the test item in the female Wistar strain rat was estimated to be
greater than 2500 mg/kg body weight.
As the median lethal dose was above 2500 mg/kg bw in an oral study
classification is not warranted.
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