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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation
Remarks:
other: Standard Draize Test
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from authorative handbook and reliable database

Data source

Reference
Reference Type:
review article or handbook
Title:
DPIM: AJS500
Author:
Richard J. Lewis, Sr.
Year:
2007
Bibliographic source:
SAX (Sax's Handbook of Dangerous Industrial Materials), (Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia.:  , 1972, 192. )

Materials and methods

Principles of method if other than guideline:
Data is from SAX and RTECS
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
- Name of test material: 4-aminoazobenzene-3, 4’-disulphonic acid- Molecular formula: C12H11N3O6S2- Molecular weight: 357.36 g/mol- Substance type: Organic

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
500 mg
Duration of treatment / exposure:
24H
Observation period (in vivo):
No data available
Number of animals or in vitro replicates:
No data available
Details on study design:
No data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 24h
Reversibility:
not specified
Remarks on result:
other: Mild irritation
Irritant / corrosive response data:
No data available
Other effects:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: Mildly irritant
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
The 4-Aminoazobenzene-3, 4’-disulfonic acid (101-50-8) was found to be mildly irritating to eye of rabbit.
Executive summary:

4-Aminoazobenzene-3, 4’-disulfonic acid (101-50-8) was administered to eye of rabbit at 500 mg of concentration for 24 hrs. Mild irritation was observed after 24 hrs.

Therefore, the 4-Aminoazobenzene-3, 4’-disulfonic acid (101-50-8) was found to be mildly irritating to eye of rabbit.