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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

By QSAR Toolbox version 3.3  predicted model the short term toxicity (LC50) in Brachydanio rerio (new name: Danio rerio) fish was estimated to be 291.161651611 mg/l for 96 hrs in static condition for test substance 4-Aminoazobenzene-3,4'-disulfonic acid with mortality effects. 

Key value for chemical safety assessment

LC50 for freshwater fish:
291.162 mg/L

Additional information

Various studies for the target chemical 4-Aminoazobenzene-3, 4’-disulfonic acid (Cas no.101-50-8) along with read across substance data were reviewed to summarize the following information:

96 hrs aquatic toxicity study (SSS QSAR prediction model, 2016) was conducted to assess toxic effects of the test compound 4-Aminoazobenzene-3, 4’-disulfonic acid (CAS no 101-50-8) and the results were predicted. This predicted study indicate that the short term toxicity (LC50) in Brachydanio rerio (new name: Danio rerio) fish to be 291.161651611 mg/l in static condition.

Other read across substance Disodium 2-amino-5-[(4-sulphonatophenyl)azo]benzenesulphonate (Cas no. 2706-28-7)study from German GSBL database;2016 indicate that the lethal concentration (LC0) value was obtained be to 1000 mg/l for 48 hrs.on mortality, immobilization and Cell proliferation inhibition effects.

On the basis of the above results of predicted data for target chemical and its read across substance, it can be concluded that the substance can be classified as non- hazardous to fish as per the criteria of CLP regulation.