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EC number: 202-947-7 | CAS number: 101-50-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Classification of 4-aminoazobenzene-3,4'-disulphonic acid for effects in the environment:
In determining the classification appropriate to 4-aminoazobenzene-3,4'-disulphonic acid, it is necessary to consider all available evidence concerning its persistence, potential to accumulate and predicted or observed environmental fate and behaviour that may present a long-term and/or delayed danger to the structure and/or functioning of aquatic ecosystems. The PBT assessment were based on toxicological information in conjunction with standardized environmental fate- and bioaccumulation models. These points are considered below.
Persistence assessment
Available predicted data indicates that 4-aminoazobenzene-3,4'-disulphonic acid is not persistent in the aquatic and soil environment. Moreover, its persistent characteristics is only observed in the sediment compartment but Fugacity modelling shows that sediment is not an important environmental fate (less than 0% when estimated by EPI Suite version 4.1). Hence it has been concluded that 4-aminoazobenzene-3,4'-disulphonic acid is not persistent in nature.
Thus, 4-aminoazobenzene-3,4'-disulphonic acid is classified as a not persistent chemical (Not P/ vP).
Bioaccumulation assessment
The BCF value was estimated based on regression based method to 3.162 L/Kg wet-weight (calculated by EPI suite version 4.1). The log Kow was also below the threshold value of 4.5 (Log Kow = -0.91). Hence, this compound was predicted to have low potential of bioaccumulation in fish and food chains.
Thus, 4-aminoazobenzene-3,4'-disulphonic acid does not satisfy the criterion for classification as bioaccumulative (Not B/vB).
Toxicity assessment
The toxicity values of fish, invertebrates and algae are LC50 = 291 and 54315.48 mg/L, EC50 = 148 mg/L and LC 50 = 2749.32 mg/L, respectively. These values suggest classification for aquatic toxicity will not be applicable for all of the tropic levels and the same is based on the above mentioned estimation studies.
In addition to aquatic toxicity, the substance, 4-aminoazobenzene-3,4'-disulphonic acid, is not classified as carcinogenic (category 1A or 1B), germ cell mutagenic (category 1A or 1B), or toxic for reproduction (category 1A, 1B or 2) according to CLP (Regulation (EC) No 1272/2008) and there is no evidence of chronic toxicity, as identified by the classification STOT (repeated exposure) according to Regulation (EC) No 1272/2008.
Thus, 4-aminoazobenzene-3,4'-disulphonic acid does not meet the Annex XIII criterion for classification as toxic (Not T).
In accordance with the requirements of Annex XIII; it can be inferred that 4-aminoazobenzene-3,4'-disulphonic acid is a not a PBT (including vPvB) substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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