Registration Dossier
Registration Dossier
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A mixture of isomers of: 1,1'-[(3,5(or 2,4 or 4,6 or 2,6)-dihydroxy-o(or m or p)-phenylene)bis(azo-meta-phenyleneazo{1-[3-(dimethylamino)propyl]-1,2-dihydro-6-hydroxy-4-methyl-2-oxopyridine-5,3-diyl})]dipyridinium-dichloride-dihydrochloride; 1-(1-[3-(dimethylamino)propyl]-5-{3-[x-(4-{1-[3-(dimethylamino)propyl]-1,6-dihydro-2-hydroxy-4-methyl-6-oxo-5-pyridinio-3-pyridylazo}phenylazo)-2,4(or 2,6 or 3,5 or 4,6)-dihydroxyphenylazo]phenylazo}-1,2-dihydro-6-hydroxy-4-methyl-2-oxo-3-pyridyl)pyridinium-dichloride-dihydrochloride (where x is variable)
EC number: 404-540-1 | CAS number: 159405-95-5 BRAUN HM 2763; BROWN HM 2763; BRUN HM 2763; BRUNO HM 2763
Endpoint summary
Administrative data
Description of key information
Skin irritation/corrosion: not irritating
Eye irritation: not irritating
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation/corrosion.
A reliable study was designed according to OECD TG 404. Under the conditions of this study, the test item was not irritating when applied to the intact rabbit skin.
Eye irritation/corrosion
A reliable study was designed according to OECD TG 405. The most severe irritation effect was conjunctival redness. One out of three animals had an average score of 2 over 24 h, 48 h and 72 h, while the two other animals had a conjunctival score of 1.67 over the three time points. Maximum individual conjunctival score at one single time point was 2. All other irritation effects were less severe. All irritation effects were fully reversible at 14 days at latest. The test article therefore should be considered not irritating to the rabbit eye.
Justification for classification or non-classification
- skin irritation/corrosion:
based on the above stated assessment, the results from reliable study show that the substance is not irritating to the skin. Therefore, the substance does not need to be classified according to the CLP Regulation (EC 1272/2008).
- eye irritation/corrosion:
based on the above stated assessment, the results from a reliable study show that the substance is not irritating to the eye. Therefore, the substance does not need to be classified according to the CLP Regulation (EC 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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