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Diss Factsheets
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EC number: 203-615-4 | CAS number: 108-78-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water and sediment: simulation tests
Administrative data
Link to relevant study record(s)
Description of key information
Surface water: A waiver is requested based on the missing readily and inherent biodegradation.
Sediment: A waiver is requested based on the Annex IX of REACH criterion "the test is required only for substances with a high potential for adsorption to soil". Melamine has a low adsorption coefficient.
Key value for chemical safety assessment
Additional information
Surface water:
Simulation tests are normally applied to chemicals which have failed a screening test for ready biodegradability, but have passed a test for inherent biodegradability. Melamine is therefore not a candidate for a simulation test, as it did not pass the tests for inherent biodegradability. For risk assessment it has to be assumed that melamine is not degraded in surface water.
Degradation nevertheless can take place under more favourable conditions, e.g. by adapted activated sludge microorganisms or if an additional energy source such as glucose was added to the system. Nitrification of ammonia groups of melamine was observed in soil or by specific microorganisms (Pseudomonas, Nitrosomonas or Klebsiella strains). The pathway and the degradation products of melamine were determined.
According to Annex VIII, IX and X of REACH "Further biotic degradation testing shall be proposed by the registrant if the chemical safety assessment according to Annex I indicates the need to investigate further the degradation of the substance and its degradation products".
Melamine has a low toxicity to aquatic organisms, not leading to a classification. Melamine does not bioaccumulate. Melamine is not a PBT or a vPvB substance. The chemical safety assessment does not indicate the need to investigate further the degradation of the substance and its degradation products.
It is concluded that the results of a simulation test are not essential for classification or for the chemical safety assessment.
Sediment:
According to Annex IX of REACH: The test is required only "for substances with a high potential for adsorption to soil". Melamine has a low potential for adsorption to soil. logKoc is estimated to 1.1 to 1.5.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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