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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study is reported in summary form only, but the results support the proposed classification
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1979

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The study is a non-guideline irritation screening study.
GLP compliance:
no
Remarks:
Pre-dates GLP; screening study

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
No further details provided

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
no
Duration of treatment / exposure:
Animals were exposed to 50 mg of the test material and observed for up to 7 days.
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
Two

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
other: not applicable
Time point:
other: not applicable
Max. score:
100
Reversibility:
not reversible
Remarks on result:
other: An overall score irritation is not given in the report. A maximum score of 100 has been added for completeness. The test substance was found to be corrosive.
Irritant / corrosive response data:
An overall score irritation is not given in the report. A maximum score of 100 has been added for completeness. The test substance was found to be corrosive.
Other effects:
Very marked reddening and corrosion are noted.

Any other information on results incl. tables

Results are reported very briefly (very marked reddening and corrosive effects).

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The results of this study indicate that chromium trioxide is corrosive.
Executive summary:

50 mg chromium trioxide instilled into one eye of two New Zealand White rabbits produced corrosive effects.