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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Limited reporting (study summary only): administration procedure not detailed

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1987

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
no
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
None given

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
Occlusive dosing: no further details reported
Duration of exposure:
24 hours
Doses:
0, 35, 55, 80, 110 and 160 mg/kg bw.
No. of animals per sex per dose:
Five
Control animals:
yes, concurrent no treatment
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Days -7, -1, 0, 7, 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other:
Statistics:
Not reported

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
57 mg/kg bw
95% CL:
>= 47 - <= 66
Mortality:
Deaths occurred at 55 mg/kg bw (3M, 2F); 80 mg/kg bw (5M, 4F); 110 mg/kg bw (5M, 5F) and 160 mg/kg bw (5M, 4F)
Deaths occurred between Days 1-12.
Clinical signs:
Signs of systemic toxicity included anogenital staining, nasal discharge, anorexia, hypothermia and prostration. Local findings at the application site
included oedema (at early time points), severe erythema and eschar formation. Skin at the application site appeared tanned and leathery.
Body weight:
Not detailed.
Gross pathology:
Pale renal cortex.
Other findings:
Potential target organs: kidney

Any other information on results incl. tables

The acute dermal LD50 of chromic aicd in the rabbit was found to be 57 mg/kg bw.

Applicant's summary and conclusion

Interpretation of results:
toxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute dermal LD50 of chromic acid was found to be 57 mg/kg bw.
Executive summary:

Chromic acid was applied for 24 hours under occlusive conditions to the shorn dorsal skin of New Zealand Whire rabbits (5/sex) at dose levels of 0, 35, 55, 80, 110 or 180 mg/kg bw. Animals were observed for 14 days.

Deaths occurred at dose levels of 55 mg/kg bw/d and greater. Signs of systemic toxicity and local dermal irritation at the application site were observed.

The acute dermal LD50 of chromic acid was found to be 57 mg/kg bw.