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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study is stated to have been performed to an acceptable protocol, but is only reported very briefly in this review.

Data source

Reference
Reference Type:
review article or handbook
Title:
Criteria Document for Hexavalent Chromium
Author:
Cross HJ et al
Year:
1997
Bibliographic source:
Institute of Occupational Health

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
not specified
Remarks:
: brief details given
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Type:
Constituent
Details on test material:
No further details reported

Test animals

Species:
rat
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
nose only
Vehicle:
other: water
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Concentrations:
Individual exposure concentrations are not reported
No. of animals per sex per dose:
Not reported
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LC50
Effect level:
104 mg/m³ air
Exp. duration:
4 h
Remarks on result:
other: sodium chromate
Sex:
male
Dose descriptor:
LC50
Effect level:
200 mg/m³ air
Exp. duration:
4 h
Remarks on result:
other: sodium dichromate
Sex:
male
Dose descriptor:
LC50
Effect level:
99 mg/m³ air
Exp. duration:
4 h
Remarks on result:
other: potassium dichromate

Any other information on results incl. tables

No further details are reported

Applicant's summary and conclusion

Interpretation of results:
very toxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The results of this study are consistent with the other available information; they show that this group of compounds is very toxic by inhalation.
Executive summary:

The UK IOH review reports the results of an acute inhalation toxicity study performed 'to currently accepted protocols' which gave 4 -hour LC50 values of 104 mg/m3 for sodium chromate, 200 mg/m3 for sodium dichromate and 99 mg/m3 for potassium dichromate.