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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Limited reporting (study summary only) of a guideline-comparable study.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1987

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Test material name: chromic acid
No further details reported

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male/female
Details on test animals and environmental conditions:
Not reported

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
No further details reported
Doses:
0, 32, 40, 50, 63, 80 & 100 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
52 mg/kg bw
95% CL:
>= 42 - <= 62
Mortality:
Deaths occurred at 32 mg/kg bw (1M, 2F), 40 mg/kg bw (1M), 50 mg/kg bw (2M, 3F), 63 mg/kg bw (3M, 4F), 80 mg.kg bw (3M, 4F) and 100 mg/kg bw (5M, 5F), within three days of dosing.
Clinical signs:
Lacrimation, hunched posture, hypoactivity, soft/reduced faeces, anogenital staining, red/brown facial staining.
Body weight:
Initial weight loss at 63 and 80 mg/kg bw; reduced initial weight gain at 32, 40 and 50 mg/kg bw. Slightly reduced overall weight gain at 80 mg/kg bw.
Gross pathology:
Findings were apparent in the stomcah, intestines, brain, kidney and lungs in decedent animals in all groups, but may have been secondary effects. No effects of treatment were apparent in animals surviving to scheduled necropsy.
Other findings:
Slightly increased liver weights

Any other information on results incl. tables

The report indicates that the primary cause of death was gastrointestinal corrosion, rather than systemic toxicity.

Applicant's summary and conclusion

Interpretation of results:
toxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute oral LD50 of chromic acid in the rat was found to be 52 (42-62) mg/kg bw in the rat. Chromic acid is classified as 'Toxic if swallowed', based on teh results of this study.
Executive summary:

Fischer 344 rats (5/sex/group) were gavaged with a single dose of chromic acid at dose levels of 0, 32, 40, 50, 63, 80 or 100 mg/kg bw and observed for 14 days. Deaths occurred in all dose groups, within 3 days of dosing. Reduced weight gain or iniital weight koss was apparent in all groups. Gross necropsy of decedents revealed corrosive effects on the gastrointestinal tract. The acute oral LD50 of chromic acid in the rat was found to be 52 (42-62) mg/kg bw