Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-659-6 | CAS number: 67-56-1
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: poisoning incident
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Ocular manifestations and complications of acute methyl alcohol intoxication.
- Author:
- Dethlefs, R. and Naraqi, S.
- Year:
- 1 978
- Bibliographic source:
- Med J Australia 2: 483-485
Materials and methods
- Study type:
- poisoning incident
- Endpoint addressed:
- acute toxicity: oral
- neurotoxicity
- Principles of method if other than guideline:
- The ocular manifestations of acute methyl alcohol intoxication were studied in 24 men during an outbreak.
- GLP compliance:
- no
Test material
- Reference substance name:
- Methanol
- EC Number:
- 200-659-6
- EC Name:
- Methanol
- Cas Number:
- 67-56-1
- Molecular formula:
- CH4O
- IUPAC Name:
- methanol
Constituent 1
Method
- Subjects:
- - Number of subjects exposed: 24
- Sex: male
- Race: Papua New Guinean - Route of exposure:
- oral
- Reason of exposure:
- intentional
- Exposure assessment:
- estimated
Results and discussion
- Results of examinations:
- Three groups were identified: Nine patients had no ocular abnormality, 7 had only transient ocular abnormalities, and eight had permanent ocular abnormalites.
Transient abnormalities included peripapillary oedema, optic disc hyperemia, diminished pupillary reactions to light, and central scotomata.
Permanent ocular abnormalities included optic disc pallor, attenuation of arterioles, sheathing of arterioles, diminished pupillary reaction to light, diminished visual acuity, central scotomata, and other nerve fibre bundle defects.
Complete blindness occurred in two patients, while severe visual deficit resulted in four others.
The incidence of permanent ocular abnormalities was found to correlate with the incidence of metabolic acidosis (p<0.01), and with the stated volume of methanol consumed (p<0.05). An inverse correlation was found between stated volume of methanol consumed and onset of blurred vision.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
