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EC number: 203-545-4
CAS number: 108-05-4
of Sprague-Dawley CD rats (10 males and 10 females) were given vinyl
acetate in the drinking water at nominal concentrations of 0, 200, 1000
or 5000 ppm (v/v) for 13 weeks. There was a dose related reduction in
water consumption throughout the study at 1000 and 5000 ppm, which is
considered to indicate a degree of unpalatability of the drinking water.
There was a slight reduction in bodyweight gain in males at 5000 ppm,
which was associated with a small reduction in food consumption compared
to the controls, but this did not attain statistical significance. There
were no toxicologically significant clinical effects and no
histopathological changes. The highest no effect level was 5000 ppm
vinyl acetate in drinking water, equivalent to an average daily dose
level of 684 mg/kg in the male rat and 810 mg/kg in the female rat.
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