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EC number: 203-545-4
CAS number: 108-05-4
Individual mean scores for conjunctival
reddening at 24, 48 and 72 hours were 0.33, 0.33 and 0.33. the overall
mean was therefore 0.33. There were no effects in the cornea or iris and
no chemosis at 24, 48 or 72 hours in any animals.
The primary eye irritation potential of
VINYLACETATE (STAB.) was investigated according to OECD test guideline
no. 405. The test item was applied by instillation of 0.1 mL into the
left eye of each of three young adult New Zealand White rabbits.
Irritation effects were scored at approximately 1, 24, 48 and 72 hours
after test item application. The instillation of VINYLACETATE (STAB.)
into the eye resulted in mild, early-onset and transient ocular changes,
such as reddening of the conjunctivae and sclerae, discharge and
chemosis at 1 hour. However at 24 hours, there were no corneal or
iridial effects and no chemosis in any animals. Slight conjunctival
reddening was present in all 3 animals at 24 hours but was not present
at 48 hours.
The overall mean score for conjunctival
reddening was 0.33 and based upon the referred classification criteria
(Commission Directive 2001/59/EC of August 06. 2001), VINYLACETATE
(STAB) is considered to be "not irritating" to the rabbit eye.
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