Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: occupational exposure caused effect observation
Adequacy of study:
supporting study
Reliability:
4 (not assignable)

Data source

Materials and methods

Study type:
poisoning incident
Endpoint addressed:
basic toxicokinetics
Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
Effects after occupational exposure
GLP compliance:
no

Method

Type of population:
occupational
Subjects:
1 operator at a refinery
Ethical approval:
not applicable
Route of exposure:
inhalation
Reason of exposure:
unintentional, occupational
Exposure assessment:
not specified
Details on exposure:
Exposure to the exhaust of an air powered dosing pump being used to blend 2–Ethylhexyl nitrate into diesel.

Results and discussion

Clinical signs:
The operator complained of severe headaches, nausea and giddiness.
Outcome of incidence:
Complete recovery within 2–3 hours of exposure ceasing

Applicant's summary and conclusion

Conclusions:
2-ethylhexyl nitrate is absorbed via the inhalation route and causes effects as known from dynamite including headache. Complete recovery within 2–3 hours of exposure ceasing indicates lowering of the internal exposure below effective levels
Executive summary:

An operator at a refinery was exposed to the exhaust of an air powered dosing pump being used to blend 2–ethylhexyl nitrate into diesel. The operator complained of severe headaches, nausea and giddiness. The operator made a complete recovery within 2–3 hours of exposure ceasing.