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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
5.24
Temp.:
40 °C
pH:
7.1

The test substance (0.0614 g) was diluted to 100 mL with the mobile phase. The test substance, thiourea and reference standards were injected in duplicate. The mean retention times and Log10 Pow values of the reference materials and test substance were as follows:

  Mean Retention Time (min) 

Log10Pow

 
 Thiourea  1.924
 Benzene 3.420  2.1 
 Toluene  4.240 2.7 
 Naphthalene  4.749 3.6 
 Phenanthrene  6.975 4.5 
 Triphenylamine  15.694 5.7 
 DDT  23.843 6.2 
 Test substance  11.378 5.24 
Conclusions:
Log10 Pow = 5.24
Partition Coefficient: 173000

Description of key information

Key value for chemical safety assessment

Log Kow (Log Pow):
5.24
at the temperature of:
40 °C

Additional information