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EC number: 237-410-6
CAS number: 13775-53-6
The LD50 value of LD50 ≤1.67 g cryolite/m2 from a field application study with blueberry flea beetle larvae is considered as the critical acute effect value for the assessment of oral exposure in terrestrial organisms.
For cryolite exposure via soil (uptake from soil matrix), no data are
available. However, it should be noted, that due to the dissolution
behaviour, it can be expected, that when cryolite is mixed to soil
matrix and gets in contact with pore water, it is dissolved to different
aluminum and fluoride species and no exposure to dissolved cryolite
occurs in soil.
Based on the information of U.S. EPA (1996), cryolite is applied
in dust and in suspended form where much of cryolite can expected to
remain in particulate form. Ingestion of cryolite is expected to be the
relevant route of exposure. The substance is considered to act
predominantly as stomach poison while it releases fluoride ions (U.S.
EPA, 1996). Fluoride ions in turn form complexes with metal containing
enzymes in stomach (Corbett et al., 1974). The available two studies on
the target organisms beet armyworm (Spondoptera exigua; Yee and
Toscano, 1998) and tobacco caterpillar (Spodoptera litura; Prasad
et al., 2000) provide evidence on that ingestion as route of exposure
and particulate form as form of exposure in combination cause increased
response to increased dose.
Two other studies with honeybee (Apis mellifera; Atkins and
Kellum, 1986) and blueberry flea beetle larvae (Altica sylvia;Forsythe
and Collins, 1994) could be used in a tentative manner for PNEC
derivation related to exposure similar to insecticidal application. The
honeybee brood LD50 of 224.5 g Cryolite/m2 is related to the application
rate as well as the results with the blueberry flea beetle larvae (LD50
≤1.67 g Cryolite/m2). Target species blueberry flea beetle (short term
field test) seemed to be more sensitive than honeybee brood. Despite of
the uncertainty regarding to whether a proper dose-response resulted in
the test with blueberry flea beetle larvae, the lower application rate
of 1.67 g/m2 from this study is considered as the critical acute effect
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