Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 237-410-6
CAS number: 13775-53-6
Reliable acute ecotoxicity test results are available for fish,
invertebrates and algae. The 96-h LC50 in Brachydanio rerio is 99
mg/L from a GLP compliant OECD guideline study (Solvay, 2008a). An OECD
guideline study is available for short-term toxicity in invertebrates,
the 48-h EC50 in Daphnia magna is 156 mg/L (IWL, 1998). The 72-h
ErC50 is 8.8 mg/L in the freshwater algae Pseudokirchneriella
subcapitata (tested as Selenastrum capricornutum), the 72-h
NOEC for growth rate is 1.0 mg/L from a GLP compliant OECD guideline
study (Solvay, 2008b).
Long-term ecotoxicity tests with fish and invertebrates are not
A GLP compliant respiration inhibition test (OECD 209) is available, the
3-h EC50 is >160 mg/L in activated sludge in a (Solvay, 2008c).
Studies with sediment and terrestrial
organisms for cryolite are not available. Due to the dissolution
of cryolite in water, it is expected, that risk assessment of water
compartment covers the realistic worst case situation also for sediment.
For cryolite exposure via soil (uptake from soil matrix), no data are
available. However, it should be noted, that due to the dissolution
behaviour, it can be expected, that when cryolite is mixed to soil
matrix and gets in contact with pore water, it is dissolved to different
aluminum and fluoride species and no exposure to dissolved cryolite
itself occurs in soil.
Based on the information of U.S. EPA (1996), cryolite is applied in dust
and in suspended form where much of cryolite can expected to remain in
particulate form. Ingestion of cryolite is expected to be the relevant
route of exposure. The substance is considered to act predominantly as
stomach poison while it releases fluoride ions (U.S. EPA, 1996).
Fluoride ions in turn form complexes with metal containing enzymes in
stomach (Corbett et al., 1974). The available two studies on the target
organisms beet armyworm (Spondoptera exigua; Yee and Toscano,
1998) and tobacco caterpillar (Spodoptera litura; Prasad et al.,
2000) provide evidence on that ingestion as route of exposure and
particulate form as form ofexposure in combination cause increased
response to increased dose.
Two other studies with honeybee (Apis mellifera; Atkins and
Kellum, 1986) and blueberry flea beetle larvae (Altica Sylvia;Forsythe
and Collins, 1994) could be used in a tentative manner for PNEC
derivation related to exposure similar to insecticidal application. The
honeybee brood LD50 of 224.5 g cryolite/m2 is related to the application
rate as well as the results with the blueberry flea beetle larvae (LD50
≤1.67 g cryolite/m2). Target species blueberry flea beetle (short term
field test) seemed to be more sensitive than honeybee brood. Despite of
the uncertainty regarding to whether a proper dose-response resulted in
the test with blueberry flea beetle larvae, the lower application rate
of 1.67 g/m2 from this study is considered as the critical acute effect
Furthermore, the lowest NOEC-value at 7 months exposure to HF of highly
sensitive plants species of 0.2 µg/m3 will be taken into consideration
for the assessment of the atmospheric compartment.
Data are not available to assess the toxicity of cryolite to birds.
However, there is a large mammalian dataset available. Furthermore, due
to the dissolution of cryolite, it is expected, that no secondary
poisoning occurs but exposure caused by cryolite is covered by the
PNECoral for fluoride.
Reliable acute ecotoxicity test results are available for fish (96-h
LC50 is 99 mg/L), Daphnia magna (48-h EC50 is 156 mg/L) and
algae. The lowest acute aquatic toxicity value is a 72-h ErC50 of 8.8
mg/L for the freshwater algae Pseudokirchneriella subcapitata (tested
as: Selenastrum capricornutum). In the same species, the 72-h
NOErC is 1.0 mg/L. Long-term tests with fish and aquatic invertebrates
are not available. As inorganic compound, cryolite is not biodegraded
but abiotic dissociation and subsequent interactions occur instead. At
present, cryolite is included in Annex I of Directive 67/548/EEC with a
classification N; R51-53 for the environment (Toxic to aquatic
organisms, may cause long-term adverse effects in the aquatic
environment). According to the EU Classification, Labelling and
Packaging of Substances and Mixtures (CLP) Regulation (EC) No.
1272/2008, cryolite is classified as Aquatic
H411 (Toxic to aquatic life with long lasting effects).
The PBT and vPvB criteria of Annex XIII to the REACH Regulation
(EC) No 1907/2006 do not apply to inorganic substances. Therefore a
PBT/vPvB assessment was not performed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Questo sito web si avvale di cookie affinché possiate usufruire della migliore esperienza sui nostri siti web.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again