Registration Dossier
Registration Dossier
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EC number: 200-838-9 | CAS number: 75-09-2
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: study with unclear GLP-status, peer-reviewed summary under auspices of WHO, restrictions in reporting
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Methylene Chloride (2nd ed)
- Author:
- WHO
- Year:
- 1 996
- Bibliographic source:
- Environmental Health Criteria 164
- Reference Type:
- publication
- Title:
- Methylene chloride and chronic renal hypertension
- Author:
- Loyke HF
- Year:
- 1 973
- Bibliographic source:
- Arch Pathol 95 (2), 130-131
Materials and methods
- Principles of method if other than guideline:
- Not specified, but the review docuements (ECH 1996) considered the study results reliable/acceptable
- GLP compliance:
- no
Test material
- Reference substance name:
- Dichloromethane
- EC Number:
- 200-838-9
- EC Name:
- Dichloromethane
- Cas Number:
- 75-09-2
- Molecular formula:
- CH2Cl2
- IUPAC Name:
- dichloromethane
- Details on test material:
- Not specified, but the review docuements (ECH 1996) considered the study results reliable/acceptable
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- not specified
Administration / exposure
- Route of administration:
- subcutaneous
- Duration of treatment / exposure:
- 17 weeks
- Frequency of treatment:
- twice a week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2000 mg/kg bw
Basis:
Results and discussion
- Details on results:
- LOAEL = 2000 mg/kg bw (2 times/week for 17 weeks)
Any other information on results incl. tables
Reduction of the systolic blood pressure of hypertensive Sprague- Dawley rats was reported after subcutaneous exposure to 2000 mg/kg twice a week for 17 weeks. No effect was found in normotensive rats. Very slight histopathological changes in the liver and lungs of hypertensive rats were described.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
