Registration Dossier
Registration Dossier
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EC number: 209-008-0 | CAS number: 552-30-7
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Algal growth inhibition: ErC50= >739 mg/L; NOEC = 739 mg/L
Key value for chemical safety assessment
- EC10 or NOEC for freshwater algae:
- 739 mg/L
Additional information
One reliable study addresses the short-term toxicity of trimellitic anhydride to unicellular aquatic algae. In this study (Knacker et al., 1993b) TMA was first treated with aqueous NaOH solution, to convert the acid anhydride to the sodium salt(s) of TMLA, and exposure in this study was consequently to sodium trimellitate (following neutralisation of excess alkali).
No toxicity was observed under these conditions: D. subspicatus 72 hour ErC50 (static): >739 mg TMA-equiv/L, 72 hour NOErC: 739 mg TMA-equiv/L; These endpoints are mean measured values and represent the highest concentration applied.
In accordance with ECHA guidance on information requirements and chemical safety assessment, Chapter R.7b: Endpoint specific guidance, theErC50 endpoint is used in DNEL derivation. This is because use of values based on biomass cannot be applied to an analysis of results from a system in exponential growth without logarithmic transformation.
Trimellitic anhydride and the more environmentally relevant trimellitic acid exhibit very low toxicity to unicellular aquatic algae.
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