Registration Dossier
Registration Dossier
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EC number: 604-314-4 | CAS number: 142844-00-6
Endpoint summary
Administrative data
Description of key information
Human epidemiology data does not suggest a sensitisation issue. Exposures to chemically similar materials ubiquitous in the environment and food stuffs and there are no case reports of sensitisation
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Because of the fibrous nature of the substance it is not feasible to conduct a local lymph node assay.There is no evidence that the components of the substance are sensitising agents. Annex XI waiver - clinical human data is available, which shows no sensitisation effects in the workforce; details described in 7.10.1 -Wirral Hospital report
Justification for classification or non-classification
No respiratory or skin sensitising effects have been observed in any animal inhalation tests. Extensive health surveillance of the workforce at the major manufactures of the substance in EU has shown no evidence of sensitisation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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