Registration Dossier

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
7 May 2001 to 21 May 2001
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2001
Report Date:
2002

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
yes, concurrent no treatment
Amount / concentration applied:
0,77 mg equivalent to 0.1 ml
Observation period (in vivo):
1, 24, 48, 72 hour
Number of animals or in vitro replicates:
3

Results and discussion

In vivo

Results
Irritation parameter:
cornea opacity score
Remarks:
iris score
Basis:
mean
Time point:
other: 24 h
Score:
3.33
Reversibility:
fully reversible within: 48 h

Applicant's summary and conclusion