Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
18 May 2001 to 14 June 2001
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2001
Report Date:
2002

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
GLP compliance:
yes
Test type:
acute toxic class method

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: feed
Vehicle:
arachis oil
Doses:
200 mg/kg and 2000 mg/kg
No. of animals per sex per dose:
sex dose number of animals number of deaths
M 200 mg/kg 3 0
F 2000 mg/kg 3 3
F 200 mg/kg 3 0
Control animals:
yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
>= 300 mg/kg bw

Any other information on results incl. tables

The acute oral median lethal dose (LD50) was estimated as being in the range of 300-500 mg/kg bodyweight.

Applicant's summary and conclusion