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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary source

Data source

Reference
Reference Type:
publication
Title:
Percutaneous Penetration Enhancers
Author:
Sasaki H. et al.
Year:
1995
Bibliographic source:
Chapter 7.1 of an unknown monograph published by CRC press, 211- 220 (1995)

Materials and methods

Type of study / information:
Review on skin penetration enhancement.

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

2 -Pyrrolidone was reported to have enhanced a penetration of a number of agents such as griseofulvin, theophylline and oxytetracycline.

Under in vitro conditions, using the same solvent in donor and receptor, 2 -Pyrrolidone is not a strong penetration enhancer for methanol, caffeine and octanol.

In another in vitro test method, the finite dose technique, a high enhancing effect was demonstrated on caffeine and aspirin.

The enhancing effect of 2 -Pyrrolidone on the penetration of hexyl nicotinate was confirmed by measuring vasodilation with laser velocimetry.

Applicant's summary and conclusion