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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Principles of method if other than guideline:
Calculation with software tool EPI-WIN (HYDROWIN, v2.00) of US-EPA
GLP compliance:
no
Analytical monitoring:
not required
Estimation method (if used):
Calculation with software tool EPI-WIN (HYDROWIN, v2.00) of US-EPA
Transformation products:
not specified
Details on hydrolysis and appearance of transformation product(s):
The estimation for aqueous hydrolysis rate constants for the active substance 2-pyrrolidone is based on the computer program HYDROWIN v2.00. It detects amides as hydrolysable functional group and gives the information that most amides hydrolyze to acids extremely slow at 25 °C and at a pH value of 7. Electronegative groups on carbon or nitrogen greatly accelerate base catalyzed hydrolysis, but alkyl groups on nitrogen retard both acid and base catalyzed processes. No neutral hydrolysis is evident.
pH:
7
Temp.:
25 °C
DT50:
> 1 yr
Type:
other: EPI-Win calculation (HYDROWIN, v2.00)
Validity criteria fulfilled:
yes
Executive summary:

An estimation regarding possible hydrolysis of 2 -pyrrolidone was done with help of software tool EPI-Win (HYDROWIN, v2.00). The test substance is expected to be stable.

Description of key information

2-Pyrrolidone is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions. QSAR calculations based on EPIWin software tool (US-EPA) confirm this justification since the test substance is assigned as stable.

Key value for chemical safety assessment

Half-life for hydrolysis:
1 yr
at the temperature of:
25 °C

Additional information