Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary literature source
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Summary Tables of Biological Tests
Author:
National Research Council Chemical-Biological Coordination Center
Year:
1952
Bibliographic source:
4: 320
Reference Type:
secondary source
Title:
Registry of Toxic Effects of Chemical Substances: Nickel (II) sulfamate
Author:
National Institute for Occupational Safety and Health
Year:
2008
Bibliographic source:
RTECS #QR9275000

Materials and methods

Principles of method if other than guideline:
Study design not reported
GLP compliance:
not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): nickel (II) sulfamate

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
Not Reported

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: isotonic saline
Details on exposure:
Not Reported
Doses:
500, 250, 125, 62.5, 31.3 mg/kg
No. of animals per sex per dose:

500 mg/kg: 5
250 mg/kg: 3
125 mg/kg: 3
62.5 mg/kg: 3
31.3 mg/kg: 3
(sex not reported)
Control animals:
not specified
Details on study design:
Not Reported
Statistics:
Not Reported

Results and discussion

Mortality:
500 mg/kg: 5/5 (day of death: 1 animal at 5 minutes, 3 at 15 minutes, one at 3 days)
250 mg/kg: 2/3 (day of death: day 3 for both animals)
125 mg/kg: 0/3
62.5 mg/kg: 0/3
31.3 mg/kg: 0/3
Clinical signs:

Animals in the high dose group (500 mg/kg) exhibited dyspnea and straining
Body weight:
Not Reported
Gross pathology:
Not Reported
Other findings:
Not Reported

Any other information on results incl. tables

Not Applicable

Applicant's summary and conclusion

Conclusions:

Not Applicable (data insufficient)
Executive summary:

STUDY RATED BY AN INDEPENDENT REVIEWER