Registration Dossier
Registration Dossier
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EC number: 211-708-6 | CAS number: 688-84-6
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicological and Pharmacological Actions of Methacrylate Monomers I: Effects on isolated perfused rabbit heart.
- Author:
- Mir GN, Lawrence WH, Autian J
- Year:
- 1 973
- Bibliographic source:
- J. Pharm. Sci. 62: 778-782
Materials and methods
- Type of study / information:
- Pharmacological effects
- Principles of method if other than guideline:
- 2-Ethylhexyl methacrylate was tested for its activity upon the isolated, perfused rabbit heart
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-ethylhexyl methacrylate
- EC Number:
- 211-708-6
- EC Name:
- 2-ethylhexyl methacrylate
- Cas Number:
- 688-84-6
- Molecular formula:
- C12H22O2
- IUPAC Name:
- 2-ethylhexyl methacrylate
- Test material form:
- liquid
Constituent 1
Results and discussion
Any other information on results incl. tables
2-Ethylhexyl methacrylate
produced a reversible effect (reduced heart rate and force
of contraction) on the isolated heart at all three
concentrations; the coronary flow rate was increased in
comparison to controls.
Applicant's summary and conclusion
- Executive summary:
2-ETHYLHEXYL METHACRYLATE at concentrations of 10-3, 10-4 and 10-5 (v/v) was investigated for activity upon isolated, perfused rabbit heart. 2-ETHYLHEXYL METHACRYLATE reduced heart rate, force of contraction, and increased coronary flow rate
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