Registration Dossier
Registration Dossier
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EC number: 211-708-6 | CAS number: 688-84-6
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
In the view of the overall available data, the current PNEC is likely to provide a more
conservative margin of safety and further testing is unlikely to provide a higher level of protection. For the sake of animal welfare, further testing in vertebrates is not necessary and not justified.
Key value for chemical safety assessment
Additional information
For 2-EHMA the two most sensitive trophic levels – fish and invertebrates – indicate almost identical ecotoxicity. From the bioaccumulation study there is an additional piece of information – fish metabolise 2-EHMA very fast so that it disappears rapidly from the test vessel and also the depuration after the end of exposure takes place within a few hours. This is directly comparable to what is observed in mammalian systems which share many common pathways and processes. Hence, bioaccumulation and a significantly lower chronic NOAEC is not expected. In conclusion, the current PNEC is likely to provide a more conservative margin of safety and further testing is unlikely to provide a higher level of protection. For the sake of animal welfare, further testing in vertebrates is not necessary and not justified.
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