Pentane-2,4-dione

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:

direct observations: clinical cases, poisoning incidents and other

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Information retrieved from secondary literature without access to original literature reference.

Data source

Reference

Reference Type:

publication

Title:

ACETYLACETONE

Author:

HSDB

Year:

2009

Bibliographic source:

HAZARDOUS SUBSTANCES DATA BANK (HSDB) search

Materials and methods

Study type:

other: Summary

Endpoint addressed:

acute toxicity: oral

acute toxicity: inhalation

acute toxicity: dermal

skin irritation / corrosion

eye irritation

Test guideline

Qualifier:

no guideline followed

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Pentane-2,4-dione

EC Number:

204-634-0

EC Name:

Pentane-2,4-dione

Cas Number:

123-54-6

Molecular formula:

C5H8O2

IUPAC Name:

pentane-2,4-dione

Details on test material:

not applicable

Method

Type of population:

not specified

Subjects:

no data

Ethical approval:

not specified

Route of exposure:

dermal

inhalation

oral

ocular

Reason of exposure:

other: unintentional, non-occupational and general

Exposure assessment:

not specified

Details on exposure:

no data

Examinations:

no data

Medical treatment:

no data

Results and discussion

Clinical signs:

2,4-Pentanedione was reported to be mildly irritating to skin and mucous membranes; vapour may cause unspecific effects such as dizziness, headache, nausea, vomiting and loss of consciousness

Results of examinations:

Exposure of humans towards 2,4-pentanedione vapour may cause unspecific effects such as dizziness, headache, nausea, vomiting and loss of consciousness. Skin irritation appears less hazardous. The acute oral toxicity is high. In humans the substance reveals moderate systemic ef-fects after inhalation.

Applicant's summary and conclusion

Conclusions:

Since this data are difficult to evaluate due to poor description of the results and the animal experiment show a weak if any local irritation after single application, which is more pronounced only after prolonged exposure.

Executive summary:

Regarding effects on humans only very little information is available. In the public literature it is described that exposure of humans towards 2,4-pentanedione vapour may cause unspecific effects such as dizziness, headache, nausea, vomiting and loss of consciousness.

Skin irritation appears less hazardous and effects are mild while eye burns similar to soap may result from a large application.

It has been reported that 2,4-pentanedione is appreciably more toxic by oral ingestion and vapor inhalation than either 1,2- or 1,4-diketones and saturated monoketones. The acute oral toxicity is high and internal consumption should be avoided. It is comparable in this respect to mesityl oxide. Breathing 2,4-pentanedione vapors may cause dizziness, headache, nausea, vomiting, and loss of consciousness. Skin irritation appears less hazardous. However, eye burns may result from a large application, similar to soap.

It is also reported that the material causes slight local irritant effects which are readily reversible and disappear after the end of exposure. In humans the substance reveals moderate systemic effects after inhalation which do not lead to death or permanent injury due to the low degree of severity. Acute local effects: 2,4-Pentanedione causes irritant effects which have been reported to be slight. Changes are readily reversible and disappear after end of exposure.

Acute systemic effects: After inhalation 2,4-pentanedione causes moderate effects and may involve both reversible and irreversible changes which are not strong enough to cause death or permanent injury. Since this data are difficult to evaluate due to poor description of the results and the animal experiment show a weak if any local irritation after single application, which is more pronounced only after prolonged exposure.