Registration Dossier
Registration Dossier
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EC number: 235-727-4 | CAS number: 12626-81-2
Additional physico-chemical information
Administrative data
- Endpoint:
- other: adsorption minimizing
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-doucmented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Electric field and vibration-assisted nanomolecule desorption and anti-biofouling for biosensor applications
- Author:
- Po-Ying J. Yeh, Jayachandran N. Kizhakkedathu,, John D. Madden, Mu. Chiao
- Year:
- 2 007
- Bibliographic source:
- Colloids and Surfaces B : Biointerfaces 59, 67-73
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Proteins were adsorbed to metal plates coated PZT surfaces. Then voltage and vibration were applied and proteins were repelled from the surface.
Fluorescence microscope studies were used to quantify the adsorbed protein. - GLP compliance:
- not specified
Test material
- Reference substance name:
- Lead titanium zirconium oxide
- EC Number:
- 235-727-4
- EC Name:
- Lead titanium zirconium oxide
- Cas Number:
- 12626-81-2
- Molecular formula:
- (Pb[Zrx,Ti1-x]O3 with 0
- IUPAC Name:
- titanium(4+) zirconium(4+) λ²-lead(2+) pentaoxidandiide
Constituent 1
Results and discussion
- Results:
- Combined effect of both electric-field and vibration, is responsible for the protein desorption.
Theoretical calculations on protein-surface interactions support this mechanism.
Applicant's summary and conclusion
- Conclusions:
- In the conditions of the study, PZT was found to present an excellent potential for the purpose of a protein-surface adsorption/desorption system.
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