Registration Dossier
Registration Dossier
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EC number: 204-886-1 | CAS number: 128-44-9
Endpoint summary
Administrative data
Description of key information
Hydrolysis:
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 5 to 5.5 yr, at pH range 7 and 200 days at pH 8 by second order hydrolysis rate constand and 38 days at pH 7 by pseudo-first order hydrolysis rate constant at 25 oC temperature. Thus, based on this half-life value, it can be concluded that the test chemical not hydrolysable in water.
Additional information
Hydrolysis:
Data available for the test chemical has been reviewed from authoritative database (HSDB, 2018)to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:
In first weight of evidence study the base catalyzed second order hydrolysis rate constant of test chemical was determined using a structure estimation method. The second order hydrolysis rate constant is determined to be 4.2 × 10-2 L/mol-sec with a corresponding half lives of 5.5 years and 200 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is naot hydrolysable.
In another study the half-life of the test chemical was determined using an estimated pseudo-first order hydrolysis rate constant of 0.000000 21/sec. The half-life of test chemical was determined to be 38 days at pH 7 and a temperature of 25°C, respectively. Based on the half-life values, it is concluded that the chemical is not hydrolysable.
In last study the base catalyzed second order hydrolysis rate constant and half life of hydrolysis of test chemical was determined using a structure estimation method. The second order hydrolysis rate constant is determined to be 4.0 × 10-2L/mol-sec with a corresponding half lives of 5 years and 200 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 5 to 5.5 yr, at pH range 7 and 200 days at pH 8 by second order hydrolysis rate constant and 38 days at pH 7 by pseudo-first order hydrolysis rate constant at 25 oC temperature. Thus, based on this half-life value, it can be concluded that the test chemical not hydrolysable in water.
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