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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The data used is considered reliable as it is taken from a study that has followed a recognised guideline and was conducted to GLP standards.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2009
Report date:
2009

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Qualifier:
according to guideline
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Reference substance name:
tert-butanol
IUPAC Name:
tert-butanol
Constituent 2
Chemical structure
Reference substance name:
2-methylpropan-2-ol
EC Number:
200-889-7
EC Name:
2-methylpropan-2-ol
Cas Number:
75-65-0
Molecular formula:
C4H10O
IUPAC Name:
2-methylpropan-2-ol
Constituent 3
Reference substance name:
tertiary butyl alcohol
IUPAC Name:
tertiary butyl alcohol

Study design

Details on sampling:
Duplicate samples were taken from test vessels at 0, 24 and 120 hours
Buffers:
- pH: 4
- Type and final molarity of buffer: 0.005 mol/L potassium hydrogen phthalate

- pH: 7
- Type and final molarity of buffer: 0.003 mol/L disodium hydrogen orthophosphate, 0.002 mol/L potassium dihydrogen orthophosphate, 0.002 mol/L sodium chloride

- pH: 9
- Type and final molarity of buffer: 0.001 mol/L disodium tetraborate, 0.002 mol/L sodium chloride
Details on test conditions:
The buffer solutions were filtered through a 0.2 um membrane filter to ensure they were sterile. Solutions were subjected to ultrasonication and degassing with nitrogen to minimise dissolved oxygen content.

Stock solutions were prepared at 0.4 g/L in the three buffer solutions
Duration of testopen allclose all
Duration:
120 h
pH:
4
Temp.:
50 °C
Initial conc. measured:
0.374 g/L
Duration:
120 h
pH:
7
Temp.:
50 °C
Initial conc. measured:
0.372 g/L
Duration:
120 h
pH:
9
Temp.:
50 °C
Initial conc. measured:
0.363 g/L
Number of replicates:
2
Positive controls:
no
Negative controls:
no

Results and discussion

Preliminary study:
Less than 10% hydrolysis seen at all 3 test pH values over 5 days at 50C. Equivalent to an environmental half-life of greater than 1 year, and indicating no need for conduct of the full test.
Transformation products:
no
Details on hydrolysis and appearance of transformation product(s):
No hydrolysis observed
Total recovery of test substance (in %)open allclose all
% Recovery:
> 98.3 - < 106
pH:
4
Temp.:
50 °C
Duration:
5 d
Remarks on result:
other: No hydrolysis observed
% Recovery:
> 96.9 - < 107
pH:
7
Temp.:
50 °C
Duration:
5 d
Remarks on result:
other: No hydrolysis observed
% Recovery:
> 99.5 - < 106
pH:
9
Temp.:
50 °C
Duration:
5 d
Remarks on result:
other: No hydrolysis observed
Dissipation DT50 of parent compound
Remarks on result:
other: No hydrolysis observed
Details on results:
No hydrolysis observed

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
Less than 10% hydrolysis seen at all 3 test pH values over 5 days at 50C. Equivalent to an environmental half-life of greater than 1 year, and indicating no need for conduct of the full test.
Executive summary:

Less than 10% hydrolysis seen at all 3 test pH values over 5 days at 50C. Equivalent to an environmental half-life of greater than 1 year, and indicating no need for conduct of the full test.