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Toxicological information

Toxicity to reproduction

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Administrative data

Endpoint:
two-generation reproductive toxicity
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Justification for type of information:
For justification of read across see category justification attached to category object.

Data source

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Type:
Constituent
Details on test material:
Name of test material (as cited in study report): 2-(2-(2-butoxy)ethoxy)ethanol
Analytical purity: purity 79.5%

Results and discussion

Results: P0 (first parental generation)

Effect levels (P0)

Dose descriptor:
NOAEC
Effect level:
> 1 000 mg/kg bw/day
Based on:
test mat.
Sex:
male/female
Remarks on result:
other: Current available data from category members suggests no adverse effects would be seen up to the limit dose shown.
Remarks:
There is no data on the toxicity to reproduction for this substance. A testing proposal has been submitted for the substance 2 -(2 -(2-methoxyethoxy)ethoxy)ethanol and the results will be read across to this substance using a category approach with appropriate additional bridging studies that are currently in progress.

Target system / organ toxicity (P0)

Critical effects observed:
no

Results: P1 (second parental generation)

Effect levels (P1)

Dose descriptor:
NOAEC
Effect level:
1 000 mg/kg bw/day
Based on:
test mat.
Sex:
male/female
Remarks on result:
other: Current available data from category members suggests no adverse effects would be seen up to the limit dose shown.
Remarks:
There is no data on the toxicity to reproduction for this substance. A testing proposal has been submitted for the substance 2 -(2 -(2-methoxyethoxy)ethoxy)ethanol and the results will be read across to this substance using a category approach with appropriate additional bridging studies that are currently in progress.

Target system / organ toxicity (P1)

Critical effects observed:
no

Results: F1 generation

Effect levels (F1)

Dose descriptor:
NOAEC
Generation:
F1
Effect level:
> 1 000 mg/kg bw/day
Based on:
test mat.
Sex:
male/female
Remarks on result:
other: Current available data from category members suggests no adverse effects would be seen up to the limit dose shown.
Remarks:
There is no data on the toxicity to reproduction for this substance. A testing proposal has been submitted for the substance 2 -(2 -(2-methoxyethoxy)ethoxy)ethanol and the results will be read across to this substance using a category approach with appropriate additional bridging studies that are currently in progress.

Target system / organ toxicity (F1)

Critical effects observed:
no

Results: F2 generation

Effect levels (F2)

Remarks on result:
not measured/tested

Overall reproductive toxicity

Reproductive effects observed:
no

Applicant's summary and conclusion