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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: restriction: early study report; short study description. Otherwise scientifically reliable

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1966
Report Date:
1966

Materials and methods

Principles of method if other than guideline:
Estimation of the approximate LD50 value according to BASF-internal standard
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
rat
Strain:
other: US rats
Sex:
male/female
Details on test animals and environmental conditions:
no data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
Observation period: 14 days
Test substance given as 2, 20 and 30% aqueous solution
Doses:
200, 1600, 3200, 4000, 5000, 6400 ccm/kg
No. of animals per sex per dose:
10
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
approximate LD50
Effect level:
ca. 5 170 mg/kg bw
Sex:
male/female
Dose descriptor:
approximate LD50
Effect level:
ca. 5.2 mL/kg bw
Remarks on result:
other: original value
Mortality:
see table below
Clinical signs:
Staggering, abdominal and lateral position, narcosis; female rats: sometimes bloody urine
Gross pathology:
sometimes bloody urine, several kidney damage

Any other information on results incl. tables

Dose (cmm/kg)   Conc. (%)  No. of animals  Dead animals within            
       1 hour  24 hours  48 hours  7 days  14 days
 6400  30  10  5/10  9/10  9/10  9/10  9/10
 5000  30  10  0/10  5/10  5/10  5/10  5/10
   30  10  1/10  3/10  3/10  3/10  3/10
 4000  30  10  0/10  1/10  1/10  1/10  1/10
   30  10  2/10  4/10  5/10  5/10  5/10
 3200  30  10  1/10  1/10  2/10  2/10  2/10
 1600  20  10  0/10  0/10  0/10  0/10  0/10
 200  2  10  0/10  0/10  0/10  0/10  0/10

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Executive summary:

In a reliable acute oral toxicity study where original data is available, male and female rats were subjected to doses of up to 6400ml/kg of 2-(2-(2-butoxyethoxy)ethoxy)ethanol and subsequently observed for a period of 14 days. An LD50 value of ~5170mg/kg was obtained.