4,4'-Isopropylidenediphenol, ethoxylated

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

Type:

log Pow

Partition coefficient:

>= 2 - <= 3.2

Temp.:

23 °C

pH:

6.3

The test item consists of a mixture of compounds with different degrees of ethoxylation. The determination according to the HPLC method yielded Log K_ow values in the range from Log K_ow 2.0 to 3.2 at 23°C and pH = 6.3 (pH of the water used for the preparation of the eluent):

Start of the distribution: Log K_ow = 2.0

Main component 1: Log K_ow = 2.4 (12.0 area %)

Main component 2: Log K_ow = 2.5 (28.8 area %)

Main component 3: Log K_ow = 2.6 (30.0 area %)

Main component 4: Log K_ow = 2.8 (17.1 area %)

Main component 5: Log K_ow = 2.8 (7.4 area %)

End of the distribution: Log K_ow = 3.2

Main components 2 and 3 are the components with the largest peak area at λ = 230 nm.

Conclusions:

The test item consists of a mixture of compounds with different degrees of ethoxylation. The determination according to the HPLC method yielded Log Kow values in the range 2.0 - 3.2 at 23°C and pH = 6.3 (pH of the water used for the preparation of the eluent).

Executive summary:

The partition coefficient of the test substance was determined in accordance with the OECD Guideline for Testing of Chemicals 117. The partition coefficient was measured according to the HPLC method. The test item consists of a mixture of compounds with different degrees of ethoxylation. The determination according to the HPLC method yielded Log K_ow values in the range 2.0 - 3.2 at 23°C and pH = 6.3 (pH of the water used for the preparation of the eluent).

Description of key information

The partition coefficient of the test substance was determined to be Log Kow 2-3.2 at 23°C and pH 6.3, and Log Kow 2.77 - 3.94 at 30°C in two tests conducted on the substance.

Key value for chemical safety assessment

Log Kow (Log Pow):

2.77

at the temperature of:

30 °C

Additional information

Two studies were conducted to assess the octanol-water partition coefficient of the test substance. Both studies were considered reliable as they were conducted on the registered substance according to OECD Testing Guideline 117, using the HPLC method. The key study gave a Log K_ow 2-3.2 at 23°C and pH 6.3. The supporting study gave a Log K_ow 2.77-3.94 at 30°C, with 78% of the test material having a Log K_ow between 3.00 and 3.2. Substances are generally considered to be bioaccumulative when the log K_ow ≥ 4.5, therefore, based on the results of these studies the test substance is unlikely to be bioaccumulative.