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Diss Factsheets
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EC number: 222-883-3 | CAS number: 3648-18-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to terrestrial plants
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to terrestrial plants: long-term
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
JUSTIFICATION OF READ ACROSS
Under Environmental conditions also Dioctyltin oxide and lauric acid were identified as hydrolysis products (section Hydrolysis: Lange 2012a)
Study for justification of read across is link via cross reference.
Read-across to DOTO due to immediate hydrolysis of DOTL- Reason / purpose for cross-reference:
- read-across: supporting information
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 208 (Terrestrial Plants Test: Seedling Emergence and Seedling Growth Test)
- Deviations:
- yes
- Remarks:
- see free test
- Principles of method if other than guideline:
- The 2nd definitive study was conduThe 2nd definitive study was conducted with the plant species soybean over a period of 21 dayscted with the plant species soybean over a period of 21 days.
Based on this experience it was suspected that these variations in germination and biomass growth might have led to statistically significant differences which were not test item related.
Further non-GLP investigations indicated that the soil texture might be less affected if the soil moisture content is lower at application (mixing), therefore the study for soybean was repeated with a reduced soil moisture content (45% instead of 50% of the MWHK) at application - GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Staatliches Gewerbeaufsichtsamt, Hildesheim, Germany
- Analytical monitoring:
- yes
- Vehicle:
- no
- Species:
- Avena sativa
- Plant group:
- Monocotyledonae (monocots)
- Species:
- Allium cepa
- Plant group:
- Monocotyledonae (monocots)
- Species:
- Beta vulgaris
- Plant group:
- Dicotyledonae (dicots)
- Species:
- Brassica napus
- Plant group:
- Dicotyledonae (dicots)
- Species:
- Lactuca sativa
- Plant group:
- Dicotyledonae (dicots)
- Species:
- Glycine max (G. soja)
- Plant group:
- Dicotyledonae (dicots)
- Test type:
- seedling emergence and seedling growth test
- Study type:
- laboratory study
- Substrate type:
- artificial soil
- Limit test:
- yes
- Total exposure duration:
- 21 d
- Remarks:
- in case of Onion 28d
- Test temperature:
- a) 12-23.4
b) 19.7-23.8 - Nominal and measured concentrations:
- 1000 - 400 - 160 - 64 - 25.6 mg/kg DW
- Reference substance (positive control):
- no
- Key result
- Species:
- Avena sativa
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Emerged Seedlings, Shoot Fresh Weight:, Shoot Height
- Remarks:
- +
- Key result
- Species:
- Allium cepa
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Emerged Seedlings, Shoot Fresh Weight:, Shoot Height
- Key result
- Species:
- Beta vulgaris
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Emerged Seedlings, Shoot Fresh Weight:, Shoot Height
- Key result
- Species:
- Brassica napus
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Emerged Seedlings, Shoot Fresh Weight:, Shoot Height
- Key result
- Species:
- Lactuca sativa
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Emerged Seedlings, Shoot Fresh Weight:, Shoot Height
- Key result
- Species:
- Glycine max (G. soja)
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Emerged Seedlings, Shoot Fresh Weight:, Shoot Height
- Validity criteria fulfilled:
- yes
- Conclusions:
- Potential toxic effects of the test item were assessed on day 7, 14 and 21 (onion additionally on day 28) by visual observations (number of emerged seedlings and phytotoxic effects) and at test end by shoot height and shoot fresh weight determination. No test item related phytotoxic effects and mortality occurred during the test period for all plant species
Reference
Description of key information
In accordance with Column 2 (Specific rules for adaptation from Column 1) of Regulation (EC) No. 1907/2006 (REACH) Annex IX, Short-term Toxicity to Plants testing (required in section 9.4.3) does not need to be conducted as the substance is not classified as hazardous for environmental effects and the chemical safety assessment concludes that the substance is of no immediate concern to the environment. The available data are adequate for classification and labelling purposes. Furthermore, direct exposure of the substance to soil is unlikely.
Potential toxic effects of the test item were assessed on day 7, 14 and 21 (onion additionally on day 28) by visual observations (number of emerged seedlings and phytotoxic effects) and at test end by shoot height and shoot fresh weight determination. No test item related phytotoxic effects and mortality occurred during the test period for all plant species
Key value for chemical safety assessment
- Long-term EC10, LC10 or NOEC for terrestrial plants:
- 1 000 mg/kg soil dw
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.